Faculty Collaboration Database

Poor prognosis in non-Caucasian patients with early-onset mycosis fungoides. J Am Acad Dermatol 2009 Feb;60(2):231-5

Date

11/26/2008

Pubmed ID

19026464

DOI

10.1016/j.jaad.2008.09.063

Scopus ID

2-s2.0-58149490970 (requires institutional sign-in at Scopus site)   64 Citations

Abstract

BACKGROUND: Mycosis fungoides (MF), the most common cutaneous T-cell lymphoma, is most often seen in middle-aged to elderly men.

OBJECTIVE: We conducted a retrospective study of the demographics and prognosis of patients with onset of MF before age 40 years.

METHODS: Demographic data (age, sex, and race) and histology from 1074 patents with cutaneous T-cell lymphoma were stratified by age of onset and race and analyzed using Chi-square test.

RESULTS: Women presented before age 40 years more often than men (P = .038). Early onset of MF was diagnosed in 30 of 92 (32.6%) African American (AA), 31 of 87 (35.6%) Hispanic, and 103 of 809 (12.7%) Caucasian patients. MF was significantly more common in AA (P = .0008) and Hispanic (P = .0002) patients. Early-onset MF was more common among 21 of 60 AA women (35%, P = .0174) and 19 of 40 Hispanic women (47.5%, P = .0002) than among 50 of 350 Caucasian women (14.5%). Progression from initial TNM stage occurred in only 5 (10%) Caucasian, one (5%) Hispanic, and 8 (38%) AA women who presented before age 40 years. Six of 8 AA women who progressed died of their disease whereas two were long-term survivors after allogeneic transplantation.

LIMITATIONS: This was a retrospective study at one cancer center.

CONCLUSION: Although MF is considered to be a disease of middle-aged men, early-onset MF is more common among AA and Hispanic women. AA women with early onset may have a poor prognosis and should be considered for more aggressive therapy, including allogeneic transplantation.

Author List

Sun G, Berthelot C, Li Y, Glass DA 2nd, George D, Pandya A, Kurzrock R, Duvic M

Author

Razelle Kurzrock MD Center Associate Director, Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Age Distribution
Age of Onset
Chi-Square Distribution
Female
Humans
Male
Mycosis Fungoides
Neoplasm Staging
Prognosis
Retrospective Studies
Risk Factors
Sex Distribution
Skin Neoplasms
Texas