Combined role of childhood maltreatment, family history, and gender in the risk for alcohol dependence. Psychol Med 2013 May;43(5):1045-57
Date
08/14/2012Pubmed ID
22883538Pubmed Central ID
PMC3767412DOI
10.1017/S0033291712001729Scopus ID
2-s2.0-84875915862 (requires institutional sign-in at Scopus site) 88 CitationsAbstract
BACKGROUND: Studies of the relationship between childhood maltreatment and alcohol dependence have not controlled comprehensively for potential confounding by co-occurring maltreatments and other childhood trauma, or determined whether parental history of alcohol disorders operates synergistically with gender and maltreatment to produce alcohol dependence. We addressed these issues using national data. Method Face-to-face surveys of 27 712 adult participants in a national survey.
RESULTS: Childhood physical, emotional and sexual abuse, and physical neglect were associated with alcohol dependence (p<0.001), controlling for demographics, co-occurring maltreatments and other childhood trauma. Attributable proportions (APs) due to interaction between each maltreatment and parental history revealed significant synergistic relationships for physical abuse in the entire sample, and for sexual abuse and emotional neglect in women (APs, 0.21, 0.31, 0.26 respectively), indicating that the odds of alcohol dependence given both parental history and these maltreatments were significantly higher than the additive effect of each alone (p<0.05).
CONCLUSIONS: Childhood maltreatments independently increased the risk of alcohol dependence. Importantly, results suggest a synergistic role of parental alcoholism: the effect of physical abuse on alcohol dependence may depend on parental history, while the effects of sexual abuse and emotional neglect may depend on parental history among women. Findings underscore the importance of early identification and prevention, particularly among those with a family history, and could guide genetic research and intervention development, e.g. programs to reduce the burden of childhood maltreatment may benefit from addressing the negative long-term effects of maltreatments, including potential alcohol problems, across a broad range of childhood environments.
Author List
Fenton MC, Geier T, Keyes K, Skodol AE, Grant BF, Hasin DSAuthor
Timothy J. Geier PhD Assistant Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Alcoholism
Child
Child Abuse
Child of Impaired Parents
Data Collection
Effect Modifier, Epidemiologic
Female
Genetic Predisposition to Disease
Humans
Interview, Psychological
Life Change Events
Male
Middle Aged
Prevalence
Risk Factors
Sex Factors
United States
Young Adult
