Faculty Collaboration Database

The correlation between calcium absorption and electrophysiological recovery in crushed rat peripheral nerves. Microsurgery 2010;30(2):138-45

Date

10/01/2009

Pubmed ID

19790186

DOI

10.1002/micr.20709

Scopus ID

2-s2.0-76549109524 (requires institutional sign-in at Scopus site)   16 Citations

Abstract

The correlation between calcium ion (Ca2+) concentration and electrophysiological recovery in crushed peripheral nerves has not been studied. Observing and quantifying the Ca2+ intensity in live normal and crushed peripheral nerves was performed using a novel microfine tearing technique and Calcium Green-1 Acetoxymethyl ester stain, a fluorescent Ca2+ indicator. Ca2+ was shown to be homogeneously distributed in the myelinated sheaths. After a crush injury, there was significant stasis in the injured zone and the portion distal to the injury. The Ca2+ has been almost completely absorbed after 24 weeks in the injured nerve to be similar to the controls. The process of the calcium absorption was correlated with the Compound Muscle Action Potential recovery process of the injured nerves. This correlation was statistically significant (r = -0.81, P < 0.05). The better understanding of this process will help us to improve nerve regeneration after peripheral nerve injury.

Author List

Yan JG, Matloub HS, Yan Y, Agresti M, Zhang LL, Jaradeh SS

Author

Hani S. Matloub MD Professor in the Plastic Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Action Potentials
Animals
Calcium
Calcium Signaling
Disease Models, Animal
Male
Nerve Crush
Nerve Regeneration
Neural Conduction
Rats
Rats, Sprague-Dawley
Recovery of Function
Sciatic Nerve