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Deep brain stimulation of the subthalamic nucleus in Parkinson's disease. WMJ 2005 Aug;104(6):35-8

Date

10/13/2005

Pubmed ID

16218314

Scopus ID

2-s2.0-27744581162 (requires institutional sign-in at Scopus site)   9 Citations

Abstract

OBJECTIVE: To evaluate the clinical effects of subthalamic nucleus deep brain stimulation in patients with Parkinson's disease within the first 12 months after surgery.

METHODS: We performed a prospective study in 8 patients with Parkinson's disease, in whom electrodes were implanted in the subthalamic nucleus bilaterally. We compared levodopa-equivalents and the scores of the Unified Parkinson's Disease Rating Scale pre- and post-operatively. The post-operative evaluation was done between 3 and 12 months after surgery.

RESULTS: Antiparkinsonian medications were reduced post-operatively by a mean of 61.5% (P < 0.01) from a levodopa-equivalent dosage of 1144.9 +/- 572.5 mg/day to 440.9 +/- 172.1 mg/day. Motor scores improved 44.4% (P < 0.01) and activities of daily living scores 38.2% (P < 0.01). Adverse events included a subcutaneous hematoma in 1 patient after internal pulse generator implantation necessitating evacuation.

CONCLUSIONS: Bilateral stimulation of the subthalamic nucleus is associated with significant improvement in motor function and reduction of antiparkinsonian medications in patients with Parkinson's disease in the first 12 months after surgery. On-state dyskinesias were greatly reduced, probably due to the reduction of total antiparkinsonian medications. The procedure is well tolerated.

Author List

Kawakami N, Jessen H, Bordini B, Gallagher C, Klootwyk J, Garell CP

Author

Brett J. Bordini MD Associate Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Aged
Antiparkinson Agents
Combined Modality Therapy
Deep Brain Stimulation
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Parkinson Disease
Statistics, Nonparametric
Stereotaxic Techniques
Subthalamic Nucleus
Treatment Outcome