In vivo diuretic actions of renal vasopressin V1 receptor stimulation in rats. Am J Physiol 1995 Mar;268(3 Pt 2):R796-807
Date
03/11/1995Pubmed ID
7900923DOI
10.1152/ajpregu.1995.268.3.R796Scopus ID
2-s2.0-0028905478 (requires institutional sign-in at Scopus site) 17 CitationsAbstract
The specific vasopressin V1 receptor agonist (V1AG; [Phe2,Ile3,Orn8]vasopressin) was infused (2.0 ng.kg-1.min-1) into the renal medullary interstitial space to determine the effects of selective medullary V1 receptor stimulation on sodium and water excretion in normal rats. Responses were compared with those of arginine vasopressin (AVP) and vasopressin V2 receptor stimulation resulting from infusion of a V1 receptor antagonist with AVP. Medullary infusion of V1AG or AVP in euvolemic rats produced no changes in hemodynamics or glomerular filtration rate. V1AG increased urine flow > 60% in euvolemic rats, whereas no change was observed with AVP. This response could not be explained by a rise of arterial pressure or by volume retention. With V2 stimulation in euvolemic rats, urine flow was decreased. In water diuretic rats, V1AG produced no change, whereas AVP infusion decreased urine flow. The results provide in vivo evidence that tubular V1 vasopressin receptor activity results in increased urine flow and thereby modulates the antidiuretic actions of vasopressin in the euvolemic state.
Author List
Ledderhos C, Mattson DL, Skelton MM, Cowley AW JrAuthor
Allen W. Cowley Jr PhD Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsArginine Vasopressin
Diuresis
Glomerular Filtration Rate
Hydrostatic Pressure
Hypertension, Renal
Kidney Medulla
Male
Natriuresis
Ornipressin
Osmolar Concentration
Rats
Rats, Sprague-Dawley
Receptors, Vasopressin
Renal Circulation
Vasopressins
