Episodic coma in a new leukodystrophy. Pediatr Neurol 2002 Feb;26(2):139-42
Date
03/19/2002Pubmed ID
11897479DOI
10.1016/s0887-8994(01)00356-3Scopus ID
2-s2.0-0036192115 (requires institutional sign-in at Scopus site) 6 CitationsAbstract
Among the leukodystrophies of a hypomyelinating nature, childhood ataxia with diffuse central nervous system hypomyelination exhibits the unique feature of rapid decrease in mental status after relatively minor head injuries or otherwise noncomplicated febrile illnesses. This article reports the case of a child with progressive spastic quadriparesis in whom unconsciousness developed repeatedly as a result of minor head trauma and required prolonged critical-care nursing. Although cognition is believed to be relatively preserved in this disorder, this child developed progressive cognitive decline. A detailed review of the literature is presented along with discussion of the potential mechanisms of neurologic deterioration.
Author List
Espay AJ, Bodensteiner JB, Patel HAuthor
Hema Patel MD Professor in the Neurology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Aspartic AcidAtaxia
Brain
Child
Choline
Coma
Creatine
Demyelinating Diseases
Epilepsy, Post-Traumatic
Head Injuries, Closed
Humans
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Male
Muscle Spasticity
Neurologic Examination
Quadriplegia
