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An angiographic method for in vivo study of arteries of the circle of Willis in small animals. Am J Physiol 1992 Nov;263(5 Pt 2):H1616-22

Date

11/01/1992

Pubmed ID

1443212

DOI

10.1152/ajpheart.1992.263.5.H1616

Scopus ID

2-s2.0-0026464492 (requires institutional sign-in at Scopus site)   9 Citations

Abstract

An X-ray imaging technique designed to allow sequential diameter measurements of the cerebral vessels in intact, anesthetized small animals under relatively physiological conditions is described. The ferret and the rabbit were chosen as potentially useful animal models for studying the cerebrovascular system because of the advantageous anatomic characteristics of these relatively small species. A commercially available and relatively inexpensive X-ray imaging system with a small focal spot provides good spatial resolution. An external carotid perfusion loop allows for 1) the introduction of low-osmolality contrast medium without changing perfusion pressure or flow and 2) measurement of internal carotid and circle of Willis pressures at the same time that the vessel images are obtained. In the present study, detection of small changes in the diameters of the small vessels is facilitated by an algorithm utilizing the X-ray absorption by the entire vessel cross section. This avoids some of the problems of edge detection for small cylindrical vessels wherein the contrast is less than optimal and diminishes as the vessel perimeter is approached.

Author List

Harder DR, Schulte ML, Clough AV, Dawson CA

Author

Anne Clough PhD Professor in the Mathematics, Statistics, and Computer Science department at Marquette University




MESH terms used to index this publication - Major topics in bold

Animals
Carotid Arteries
Cerebral Angiography
Cerebral Arteries
Circle of Willis
Equipment and Supplies
Ferrets
Mathematics
Papaverine
Rabbits
Time Factors
Videotape Recording