Down-regulation of trkA mRNA within nucleus basalis neurons in individuals with mild cognitive impairment and Alzheimer's disease. J Comp Neurol 2001 Aug 27;437(3):296-307
Date
08/09/2001Pubmed ID
11494257DOI
10.1002/cne.1284Scopus ID
2-s2.0-0035959515 (requires institutional sign-in at Scopus site) 67 CitationsAbstract
Recent studies indicate that trkA expression is reduced in end-stage Alzheimer's disease (AD). However, understanding the neuropathologic correlates of early cognitive decline, as well as the changes that underlie the transition from nondemented mild cognitive impairment (MCI) to AD, are more critical neurobiological challenges. In these regards, the present study examined the expression of trkA mRNA in individuals diagnosed with MCI and AD from a cohort of people enrolled in a Religious Orders Study. Individuals with MCI and AD displayed significant reductions in trkA mRNA relative to aged-matched controls, indicating that alterations in trkA gene expression occur early in the disease process. The magnitude of change was similar in MCI and AD cases, suggesting that further loss of trkA mRNA is not necessarily associated with the transition of individuals from nondemented MCI to AD. The loss of trkA mRNA was not associated with education, apolipoprotein E allele status, gender, Braak score, global cognitive score or Mini-Mental Status Examination. In contrast, the loss of trkA mRNA in MCI and AD was significantly correlated with function on a variety of episodic memory tests.
Author List
Chu Y, Cochran EJ, Bennett DA, Mufson EJ, Kordower JHAuthor
Elizabeth J. Cochran MD Adjunct Professor in the Pathology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgedAged, 80 and over
Alzheimer Disease
Basal Nucleus of Meynert
Cell Size
Disability Evaluation
Disease Progression
Down-Regulation
Female
Gene Expression Regulation
Humans
Immunohistochemistry
Male
Neurons
Neuropsychological Tests
RNA, Messenger
Receptor, trkA
