Polyploid cardiomyocytes: implications for heart regeneration. Development 2021 Jul 15;148(14)
Date
12/14/2021Pubmed ID
34897388Pubmed Central ID
PMC8326922DOI
10.1242/dev.199401Scopus ID
2-s2.0-85112764604 (requires institutional sign-in at Scopus site) 26 CitationsAbstract
Terminally differentiated cells are generally thought to have arrived at their final form and function. Many terminally differentiated cell types are polyploid, i.e. they have multiple copies of the normally diploid genome. Mammalian heart muscle cells, termed cardiomyocytes, are one such example of polyploid cells. Terminally differentiated cardiomyocytes are bi- or multi-nucleated, or have polyploid nuclei. Recent mechanistic studies of polyploid cardiomyocytes indicate that they can limit cellular proliferation and, hence, heart regeneration. In this short Spotlight, we present the mechanisms generating bi- and multi-nucleated cardiomyocytes, and the mechanisms generating polyploid nuclei. Our aim is to develop hypotheses about how these mechanisms might relate to cardiomyocyte proliferation and cardiac regeneration. We also discuss how these new findings could be applied to advance cardiac regeneration research, and how they relate to studies of other polyploid cells, such as cancer cells.
Author List
Kirillova A, Han L, Liu H, Kühn BAuthor
Lu Han PhD Assistant Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsHeart
Humans
Myocytes, Cardiac
Polyploidy
Regeneration
