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Dupuytren Cords Do Not Undergo Significant Histopathological Change After Collagenase Clostridium Histolyticum Injection. Hand (N Y) 2023 Sep;18(6):912-917



Pubmed ID


Pubmed Central ID




Scopus ID

2-s2.0-85124072507 (requires institutional sign-in at Scopus site)


Background: Dupuytren disease creates thickened cords of the palmar fascia, leading to progressive flexion contractures that severely hinder hand function. Collagenase clostridium histolyticum (CCH) injection is a common, minimally invasive alternative to surgical excision of these cords. The impact of CCH injection on the histological architecture of Dupuytren cords has not been studied extensively. Methods: A series of 10 CCH-injected cords were evaluated histologically. Cellularity, architecture, and connective tissue organization were compared against uninjected Dupuytren cords and normal palmar fascia. Results: No significant histopathological differences between CCH-injected and CCH-uninjected cords were identified. Conclusions: Dupuytren cords do not demonstrate histological changes with prior exposure to CCH.

Author List

Guo M, Yang K, Kock ND, Daley R, Dzwierzynski W, LoGiudice J, Hettinger P, Best C, Argenta A


William W. Dzwierzynski MD Professor in the Plastic Surgery department at Medical College of Wisconsin
John A. LoGiudice MD Professor in the Plastic Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Dupuytren Contracture
Injections, Intralesional
Microbial Collagenase
Treatment Outcome