Tau epitope display in progressive supranuclear palsy and corticobasal degeneration. J Neurocytol 2004 May;33(3):287-95
Date
10/12/2004Pubmed ID
15475684DOI
10.1023/B:NEUR.0000044190.96426.b9Scopus ID
2-s2.0-20844439375 (requires institutional sign-in at Scopus site) 36 CitationsAbstract
Filamentous aggregates of the protein tau are a prominent feature of Alzheimer's disease (AD), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). However, the extent to which the molecular structure of the tau in these aggregates is similar or differs between these diseases is unclear. We approached this question by examining these disorders with a panel of antibodies that represent different structural, conformational, and cleavage-specific tau epitopes. Although each of these antibodies reveals AD pathology, they resolved into three classes with respect to PSP and CBD: AD2 and Tau-46.1 stained the most tau pathology in all cases; Tau-1, 2, 5, and 12 exhibited variable reactivity; and Tau-66 and MN423 did not reveal any tau pathology. In addition, hippocampal neurofibrillary tangles in these cases showed a predominantly PSP/CBD-like, rather than AD-like, staining pattern. These results indicate that the patterns of the tau epitopes represented by this panel that reside in the pathological aggregates of PSP and CBD are similar to each other but distinct from that of AD.
Author List
Berry RW, Sweet AP, Clark FA, Lagalwar S, Lapin BR, Wang T, Topgi S, Guillozet-Bongaarts AL, Cochran EJ, Bigio EH, Binder LIAuthor
Elizabeth J. Cochran MD Adjunct Professor in the Pathology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgedAged, 80 and over
Alzheimer Disease
Antibody Specificity
Astrocytes
Biomarkers
Epitope Mapping
Epitopes
Female
Humans
Immunohistochemistry
Male
Middle Aged
Neurodegenerative Diseases
Neurofibrillary Tangles
Neurons
Supranuclear Palsy, Progressive
tau Proteins
