Faculty Collaboration Database

CHARACTERISTICS OF PIGMENTED LESIONS IN TYPE 2 IDIOPATHIC MACULAR TELANGIECTASIA. Retina 2018 Jan;38 Suppl 1(Suppl 1):S43-S50

Date

11/03/2017

Pubmed ID

29095354

Pubmed Central ID

PMC5726940

DOI

10.1097/IAE.0000000000001842

Scopus ID

2-s2.0-85042614696 (requires institutional sign-in at Scopus site)   27 Citations

Abstract

PURPOSE: Pigment in the midretina is a characteristic sign in Type 2 idiopathic macular telangiectasia (MacTel) and is considered to characterize the late stage of the disease. Our aim was to investigate its incidence, and relationship with risk factors for MacTel, including outer retinal vascularization and subretinal neovascular proliferation (SRNV).

METHODS: Pigment extent was measured in fundus autofluorescence images of 150 eyes of 75 MacTel probands, using the Region Finder tool of Heidelberg Eye Explorer. A linear mixed model was used to analyze the dynamics of pigment and its associations with other features of the phenotype. The relative incidence of pigment and of outer retinal outer retinal vascularization and SRNV was analyzed within the full MacTel Study cohort (1,244 probands).

RESULTS: Mean pigment area at baseline was 0.157 mm (range = 0-1.295 mm, SD = 0.228 mm, n = 101). Progression demonstrated a nonlinear pattern (P < 0.001) at an overall rate of 0.0177 mm/year and was associated with the initial plaque size and with SRNV. There was a strong correlation between fellow eyes (P ≤ 0.0001). In approximately 25% of all SRNV cases, SRNV may coincide with or precede pigment.

CONCLUSION: Our data may be useful for refining the current system for staging disease severity in MacTel.

Author List

Leung I, Sallo FB, Bonelli R, Clemons TE, Pauleikhoff D, Chew EY, Bird AC, Peto T, MacTel Study Group

MESH terms used to index this publication - Major topics in bold

Female
Fluorescein Angiography
Follow-Up Studies
Fundus Oculi
Humans
Macula Lutea
Male
Middle Aged
Ophthalmoscopy
Prospective Studies
Retinal Pigment Epithelium
Retinal Pigments
Telangiectasia, Hereditary Hemorrhagic
Time Factors
Tomography, Optical Coherence
Visual Acuity