Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Severe hypercholesterolemia mediated by lipoprotein X in patients with chronic graft-versus-host disease of the liver. Bone Marrow Transplant 2005 Jan;35(1):85-9

Date

11/09/2004

Pubmed ID

15531904

DOI

10.1038/sj.bmt.1704739

Scopus ID

2-s2.0-11844255681 (requires institutional sign-in at Scopus site)   44 Citations

Abstract

We describe a series of cases of extreme hypercholesterolemia mediated by lipoprotein X in patients with chronic graft-versus-host disease of the liver after an allogeneic bone marrow transplant. All of the patients presented with a total cholesterol in excess of 1000 mg/dl (25.9 mmol/l). At the time they were also noted to have pseudohyponatremia. Cholesterol appeared to be predominantly carried by lipoprotein X. Intrahepatic cholestasis leading to reflux of bile lipoproteins into the bloodstream and subsequent formation of protein X appears to be the mechanism underlying this phenomenon. Complications, including retinal cholesterol thromboembolism and cholesteroloma of the lung have been seen in the patient with the highest cholesterol levels. Severe hypercholesterolemia is an important, and likely more common than previously reported, long-term complication of allogeneic hematopoietic stem cell transplantation. It is important for clinicians to familiarize themselves with the diagnostic and therapeutic challenges this condition presents.

Author List

Turchin A, Wiebe DA, Seely EW, Graham T, Longo W, Soiffer R

Author

Walter L. Longo MD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Bone Marrow Transplantation
Cholestasis
Cholesterol
Female
Graft vs Host Disease
Humans
Hypercholesterolemia
Lipoprotein-X
Liver
Liver Diseases
Male
Middle Aged
Time Factors
Transplantation, Homologous