Clinical trial depleting T lymphocytes from donor marrow for matched and mismatched allogeneic bone marrow transplants. Cancer Treat Rep 1985 Apr;69(4):377-86
Date
04/01/1985Pubmed ID
3888387Scopus ID
2-s2.0-0021999060 (requires institutional sign-in at Scopus site) 58 CitationsAbstract
Nine patients received T-lymphocyte-depleted histocompatible bone marrow and 28 patients received T-lymphocyte-depleted histoincompatible bone marrow. Eight of nine patients receiving matched bone marrow quickly engrafted without severe graft-versus-host disease (GvHD). None of the eight patients received anti-GvHD prophylaxis medications. Two of these eight patients are currently alive. Nonengraftment and severe GvHD were problems seen in some of the patients given the histoincompatible bone marrow. Additional cytarabine pretransplant permitted engraftment in those patients undergoing histoincompatible transplants for treatment of malignancy, and prednisone and cyclosporine posttransplant reduced the incidence of acute GvHD in those given T-lymphocyte-depleted grafts. Seven of these 28 patients are currently alive. T-lymphocyte-depleted marrow can reduce the occurrence or prevent severe acute GvHD, especially when combined with additional prednisone and cyclosporine; however, the impact on relapse patterns and survival remains to be determined. The occurrence of nonengraftment and treatment-related lymphomas are formidable problems to overcome.
Author List
Trigg ME, Billing R, Sondel PM, Exten R, Hong R, Bozdech MJ, Horowitz SD, Finlay JL, Moen R, Longo WAuthor
Walter L. Longo MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Anemia, Aplastic
Bone Marrow Transplantation
Child
Child, Preschool
Clinical Trials as Topic
Cyclophosphamide
Cyclosporins
Cytarabine
Evaluation Studies as Topic
Female
Graft vs Host Disease
HLA Antigens
Histocompatibility
Humans
Immunologic Deficiency Syndromes
Infant
Leukemia, Lymphoid
Leukemia, Myeloid
Male
Prednisone
Rosette Formation
T-Lymphocytes