Epstein-Barr virus-associated intracranial leiomyosarcoma in an HIV-positive adolescent. J Pediatr Hematol Oncol 2010 May;32(4):e144-7
Date
03/13/2010Pubmed ID
20224440DOI
10.1097/MPH.0b013e3181c80bf3Scopus ID
2-s2.0-77952768659 (requires institutional sign-in at Scopus site) 31 CitationsAbstract
A 17-year-old African American female with human immunodeficiency virus infection presented with an unresectable intracranial neoplasm with mass effect upon the brainstem. Stereotactic biopsy revealed an Epstein-Barr virus (EBV)-associated leiomyosarcoma. Radiation therapy and gemcitabine were used to shrink the mass with the aim to make it surgically resectable. Prolonged neutropenia and recurrent skin infections led to the discontinuation of gemcitabine. The mass stabilized after radiation therapy and has decreased in size in 15 months of follow-up. EBV has been demonstrated in most smooth muscle tumors associated with acquired immunodeficiency syndrome and other immunocompromised states. This is the first documented case of an EBV-positive intracranial leiomyosarcoma in a pediatric human immunodeficiency virus patient.
Author List
Gupta S, Havens PL, Southern JF, Firat SY, Jogal SSAuthor
Selim Firat MD Professor in the Radiation Oncology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentBrain Neoplasms
Epstein-Barr Virus Infections
Female
HIV Seropositivity
HIV-1
Herpesvirus 4, Human
Humans
In Situ Hybridization
Leiomyosarcoma
Magnetic Resonance Imaging
RNA, Viral
Treatment Outcome
