Faculty Collaboration Database

Orbital myositis as a paraneoplastic syndrome. Arch Ophthalmol 1994 Mar;112(3):380-6

Date

03/01/1994

Pubmed ID

8129665

DOI

10.1001/archopht.1994.01090150110032

Scopus ID

2-s2.0-0028269385 (requires institutional sign-in at Scopus site)   61 Citations

Abstract

We describe a patient with bilateral orbital myositis, multiple cranial neuropathies, a sensory polyneuropathy, serum and cerebrospinal fluid paraproteins, and high-grade non-Hodgkin's lymphoma. Neurologic symptoms began more than 1 year before diagnosis of the lymphoma. Results of extraocular muscle biopsy showed extensive destruction of myofibers and granulomatous features, with no evidence of direct tumor involvement. The cranial neuropathies and orbital myositis improved with immunosuppressive therapy, while the patient's tumor progressed. We believe the orbital myositis and the multiple neurologic abnormalities were paraneoplastic effects of the lymphoma. To our knowledge, this is the first case of orbital myositis identified as a paraneoplastic syndrome.

Author List

Harris GJ, Murphy ML, Schmidt EW, Hanson GA, Dotson RM

Author

Gerald J. Harris MD Professor in the Ophthalmology and Visual Sciences department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Cranial Nerve Diseases
Humans
Lymphoma, B-Cell
Male
Myositis
Oculomotor Muscles
Orbital Diseases
Paraneoplastic Syndromes
Paraproteinemias
Tomography, X-Ray Computed