Faculty Collaboration Database

Pediatric Donor Cell Acute Lymphoblastic Leukemia Following Bone Marrow Transplant for GATA2 Mutation. J Pediatr Hematol Oncol 2022 Jul 01;44(5):268-270

Date

03/03/2022

Pubmed ID

35235548

DOI

10.1097/MPH.0000000000002437

Scopus ID

2-s2.0-85129146818 (requires institutional sign-in at Scopus site)   3 Citations

Abstract

Donor cell leukemia is a rare complication following hematopoietic stem cell transplant (HSCT). There are currently few reports in children and only rare, reported cases of donor-derived myelodysplastic syndrome/acute myeloid leukemia in patients with an underlying germline GATA2 mutation. Most reported cases are myeloid in origin and occur following related HSCT. We present a 3-year-old female who developed a donor-derived B-cell acute lymphoblastic leukemia 2 years post unrelated HSCT for GATA2 germline mutation.

Author List

Scheuermann A, Moskop A, Hopp A, Bone K, Drendel HM, Talano J, Harker-Murray P, Astle J

Authors

Kathleen M. Bone PhD Associate Professor in the Pathology department at Medical College of Wisconsin
Paul D. Harker-Murray MD, PhD Professor in the Pediatrics department at Medical College of Wisconsin
Amy Moskop MD Assistant Professor in the Pediatrics department at Medical College of Wisconsin
Julie-An M. Talano MD Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Child
Child, Preschool
Female
GATA2 Transcription Factor
Hematopoietic Stem Cell Transplantation
Humans
Leukemia, Myeloid, Acute
Mutation
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Unrelated Donors