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Pediatric Donor Cell Acute Lymphoblastic Leukemia Following Bone Marrow Transplant for GATA2 Mutation. J Pediatr Hematol Oncol 2022 07 01;44(5):268-270

Date

03/03/2022

Pubmed ID

35235548

DOI

10.1097/MPH.0000000000002437

Scopus ID

2-s2.0-85129146818

Abstract

Donor cell leukemia is a rare complication following hematopoietic stem cell transplant (HSCT). There are currently few reports in children and only rare, reported cases of donor-derived myelodysplastic syndrome/acute myeloid leukemia in patients with an underlying germline GATA2 mutation. Most reported cases are myeloid in origin and occur following related HSCT. We present a 3-year-old female who developed a donor-derived B-cell acute lymphoblastic leukemia 2 years post unrelated HSCT for GATA2 germline mutation.

Author List

Scheuermann A, Moskop A, Hopp A, Bone K, Drendel HM, Talano J, Harker-Murray P, Astle J

Authors

John M. Astle MD, PhD Assistant Professor in the Pathology department at Medical College of Wisconsin
Kathleen M. Bone PhD Assistant Professor in the Pathology department at Medical College of Wisconsin
Paul D. Harker-Murray MD, PhD Associate Professor in the Pediatrics department at Medical College of Wisconsin
Amy Moskop MD Assistant Professor in the Pediatrics department at Medical College of Wisconsin
Julie-An M. Talano MD Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Child
Child, Preschool
Female
GATA2 Transcription Factor
Hematopoietic Stem Cell Transplantation
Humans
Leukemia, Myeloid, Acute
Mutation
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Unrelated Donors