Pediatric Donor Cell Acute Lymphoblastic Leukemia Following Bone Marrow Transplant for GATA2 Mutation. J Pediatr Hematol Oncol 2022 Jul 01;44(5):268-270
Date
03/03/2022Pubmed ID
35235548DOI
10.1097/MPH.0000000000002437Scopus ID
2-s2.0-85129146818 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
Donor cell leukemia is a rare complication following hematopoietic stem cell transplant (HSCT). There are currently few reports in children and only rare, reported cases of donor-derived myelodysplastic syndrome/acute myeloid leukemia in patients with an underlying germline GATA2 mutation. Most reported cases are myeloid in origin and occur following related HSCT. We present a 3-year-old female who developed a donor-derived B-cell acute lymphoblastic leukemia 2 years post unrelated HSCT for GATA2 germline mutation.
Author List
Scheuermann A, Moskop A, Hopp A, Bone K, Drendel HM, Talano J, Harker-Murray P, Astle JAuthors
Kathleen M. Bone PhD Associate Professor in the Pathology and Laboratory Medicine department at Medical College of WisconsinPaul D. Harker-Murray PhD, MD Professor in the Pediatrics department at Medical College of Wisconsin
Amanda Hopp MD Assistant Professor in the Pathology and Laboratory Medicine department at Medical College of Wisconsin
Amy Moskop MD Associate Professor in the Pediatrics department at Medical College of Wisconsin
Julie-An M. Talano MD Professor in the Pediatrics department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
ChildChild, Preschool
Female
GATA2 Transcription Factor
Hematopoietic Stem Cell Transplantation
Humans
Leukemia, Myeloid, Acute
Mutation
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Unrelated Donors
