Faculty Collaboration Database

Increasing incidence of adenovirus disease in bone marrow transplant recipients. J Infect Dis 1994 Apr;169(4):775-81

Date

04/01/1994

Pubmed ID

8133091

DOI

10.1093/infdis/169.4.775

Scopus ID

2-s2.0-0028256278 (requires institutional sign-in at Scopus site)   314 Citations

Abstract

Adenovirus infections in 201 bone marrow transplant (BMT) recipients over 4 years were retrospectively reviewed. Forty-two patients (20.9%) had positive adenovirus cultures after BMT. There was a higher incidence of adenovirus infections in pediatric patients than in adults (31.3% vs. 13.6%, P = .003). In addition, the time of onset of adenovirus infection after transplant was earlier in pediatric patients (mean, < 30 days) than in adults (> 90 days). Adenovirus type 35 was the most common serotype identified. One-third of adenovirus-positive patients had definite or probable adenovirus disease. Moderate to severe acute graft-versus-host disease and isolation of adenovirus from two or more sites were significant risk factors for adenovirus disease. This report documents a higher incidence of both adenovirus infection and disease than do previous studies. Adenovirus may emerge as a more frequent pathogen as more high-risk BMT transplants are done.

Author List

Flomenberg P, Babbitt J, Drobyski WR, Ash RC, Carrigan DR, Sedmak GV, McAuliffe T, Camitta B, Horowitz MM, Bunin N

Authors

William R. Drobyski MD Professor in the Medicine department at Medical College of Wisconsin
Mary M. Horowitz MD, MS Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adenovirus Infections, Human
Adenoviruses, Human
Adolescent
Adult
Age Factors
Anemia, Aplastic
Bone Marrow Transplantation
Child
Child, Preschool
Cohort Studies
Female
Graft vs Host Disease
Humans
Incidence
Infant
Leukemia
Lymphoma
Male
Middle Aged
Myelodysplastic Syndromes
Retrospective Studies
Risk Factors
Serotyping
Time Factors