Faculty Collaboration Database

Predictors of von Willebrand disease in children. Pediatr Blood Cancer 2012 May;58(5):736-40

Date

01/13/2012

Pubmed ID

22237978

DOI

10.1002/pbc.23411

Scopus ID

2-s2.0-84857827084 (requires institutional sign-in at Scopus site)   8 Citations

Abstract

BACKGROUND: Bleeding and bruising are common symptoms for which children are referred to a pediatric hematologist. Although bleeding scores have been validated to quantify bleeding risk in adults, there are no similar definitive data in children. The aim was to describe presenting bleeding symptoms in children and evaluate if these bleeding symptoms were predictive of von Willebrand disease (VWD) or low von Willebrand factor (VWF).

PROCEDURE: We performed a retrospective chart review of consecutive pediatric patients referred for perceived bleeding symptoms to the coagulation clinic at The Children's Hospital of Pittsburgh of UPMC. All underwent a uniform bleeding symptom inventory and hemostatic testing. Single and multiple variable logistic regression models were created to predict either VWD, low VWF, or nonspecific defective platelet aggregation, using the predictor variables of family bleeding history, mucocutaneous bleeding, cutaneous bleeding, and surgical bleeding, based on The International Society on Thrombosis and Hemostasis (ISTH) bleeding definitions.

RESULTS: Of 298 pediatric patients evaluated, 8% had VWD (VWF:RCo and VWF:Ag ≤ 30 IU/dl) and 34% had low VWF (VWF:RCo and VWF:Ag 30-50 IU/dl). Further, 16% had a nonspecific platelet aggregation disorder, 41% had normal hemostatic testing, and 1% had factor VIII or IX deficiency. In single and multiple variable logistic regression analysis, neither a personal or family bleeding history at presentation, nor the presence of two or more bleeding symptoms were predictive of VWD, low VWF, or nonspecific defective platelet aggregation.

CONCLUSIONS: These findings suggest that qualitative assessment of bleeding symptoms alone is not useful in children.

Author List

Sidonio RF Jr, Gunawardena S, Shaw PH, Ragni M

Author

Peter H. Shaw MD Associate Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Child
Child, Preschool
Female
Humans
Infant
Logistic Models
Male
Retrospective Studies
von Willebrand Diseases