Faculty Collaboration Database

Detection of EBV DNA in the cord blood donor for a patient developing Epstein-Barr virus-associated lymphoproliferative disorder following mismatched unrelated umbilical cord blood transplantation. Bone Marrow Transplant 2001 Apr;27(7):761-5

Date

05/22/2001

Pubmed ID

11360119

DOI

10.1038/sj.bmt.1702770

Scopus ID

2-s2.0-0035038235 (requires institutional sign-in at Scopus site)   17 Citations

Abstract

Epstein-Barr virus-associated post-transplant lymphoproliferative disorder (PTLD) has been well described as a complication following allogeneic stem cell transplantation but has only recently been reported following umbilical cord blood (UCB) transplant. We report the case of a child transplanted with unrelated mismatched UCB for juvenile chronic myelogenous leukemia (JCML) who developed EBV-associated PTLD, which was confirmed pathologically, 139 days following stem cell infusion. There was no clinical response to reduction of immune suppression, high-dose acyclovir, or alpha interferon. The patient died 160 days after transplantation. EBV was detected by polymerase chain reaction in the cord blood unit used for transplantation. This case demonstrates that EBV-associated PTLD can occur following mismatched unrelated UCB transplant and may be related to transmission of EBV infection by donor lymphocytes.

Author List

Haut PR, Kovarik P, Shaw PH, Walterhouse D, Jenson HB, Kletzel M

Author

Peter H. Shaw MD Associate Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

B-Lymphocytes
Blood Donors
Child, Preschool
DNA, Viral
Epstein-Barr Virus Infections
Fatal Outcome
Fetal Blood
Hematopoietic Stem Cell Transplantation
Herpesvirus 4, Human
Histocompatibility
Histocompatibility Testing
Humans
Lymphoproliferative Disorders
Male