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Periocular lymphoproliferative diseases: natural history, prognostic factors, and treatment. Radiology 1992 Oct;185(1):63-70



Pubmed ID




Scopus ID

2-s2.0-0026675762   8 Citations


A study was undertaken to assess the natural history of periocular lymphoproliferative diseases, identify key prognostic factors, and clarify the role of orbital irradiation. Thirty-four patients with periocular lymphoproliferative disease were treated with orbital irradiation between 1975 and 1990. Eight patients had atypical lymphoid infiltrate, and 26 had malignant lymphoma. Forty-three eyes were irradiated with en-face electrons or 6-MV photons. Five-year disease-free survival for all stages was 65%; it was not significantly affected by bilaterality or site. Stage, distinction between atypical lymphoid infiltrate and malignant lymphoma, and working formulation grade were important prognostic indicators. A complete response during irradiation was achieved in 24 of 43 (56%) eyes at a median dose of 2,400 cGy, and a partial response was achieved in 19 (44%), with resolution at a median of 2.8 months. Patients with periocular reactive lymphoid hyperplasia or atypical lymphoid infiltrate may have or are at significant risk of developing lymphoma and dissemination. Local treatment remains important; orbital irradiation achieves prompt local control with acceptable morbidity.

Author List

Erickson BA, Harris GJ, Enke CA, Murray KJ, Massaro BM, Hanson GA, Hansen RM, Anderson T, Wilson JF


Beth A. Erickson MD Professor in the Radiation Oncology department at Medical College of Wisconsin
Gerald J. Harris MD Professor in the Ophthalmology and Visual Sciences department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Aged, 80 and over
Middle Aged
Orbital Neoplasms
Radiation Dosage
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a