Motor activity and transit in the autonomically denervated jejunum. Am J Surg 1994 Jan;167(1):80-8
Date
01/01/1994Pubmed ID
8311144DOI
10.1016/0002-9610(94)90057-4Scopus ID
2-s2.0-0028040354 (requires institutional sign-in at Scopus site) 26 CitationsAbstract
The role of extrinsic (autonomic) innervation in postprandial contractile activity of the small intestine is unknown. Using a canine model, we investigated the effects of complete extrinsic denervation on the parameters of fasting and postprandial jejunal contractions and their relationship to intestinal transit. Individual contractions were recorded using strain gauge transducers. Spatial and temporal parameters of contractions were analyzed by computer methods. Bolus injection of 14C-polyethylene glycol was used to calculate intestinal transit rates. Statistical comparisons of control and denervated animals were made by nonparametric tests. Extrinsic denervation did not abolish fasting or fed motor activity, but the following effects were observed: (1) the frequency of migrating motor complexes (MMCs) increased; (2) the onset of fed motor activity was delayed, and the duration of fed activity was shortened; (3) frequency, mean amplitude, and mean area of postprandial contractions were decreased; (4) fewer contractions propagated distally, and mean propagation distance was shortened; and (5) intestinal transit was slower for solids, but not for liquids. In the small intestine, extrinsic nerves modulate motor activity, which is under primary control of the intrinsic (enteric) nervous system.
Author List
Johnson CP, Sarna SK, Cowles VE, Osborn JL, Zhu YR, Bonham L, Buchmann E, Baytiyeh R, Telford GL, Roza AMAuthor
Christopher P. Johnson MD Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAutonomic Denervation
Autonomic Nervous System
Dogs
Enteric Nervous System
Fasting
Female
Food
Gastrointestinal Transit
Jejunum
Male
Myoelectric Complex, Migrating
