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Motor activity and transit in the autonomically denervated jejunum. Am J Surg 1994 Jan;167(1):80-8

Date

01/01/1994

Pubmed ID

8311144

DOI

10.1016/0002-9610(94)90057-4

Scopus ID

2-s2.0-0028040354   24 Citations

Abstract

The role of extrinsic (autonomic) innervation in postprandial contractile activity of the small intestine is unknown. Using a canine model, we investigated the effects of complete extrinsic denervation on the parameters of fasting and postprandial jejunal contractions and their relationship to intestinal transit. Individual contractions were recorded using strain gauge transducers. Spatial and temporal parameters of contractions were analyzed by computer methods. Bolus injection of 14C-polyethylene glycol was used to calculate intestinal transit rates. Statistical comparisons of control and denervated animals were made by nonparametric tests. Extrinsic denervation did not abolish fasting or fed motor activity, but the following effects were observed: (1) the frequency of migrating motor complexes (MMCs) increased; (2) the onset of fed motor activity was delayed, and the duration of fed activity was shortened; (3) frequency, mean amplitude, and mean area of postprandial contractions were decreased; (4) fewer contractions propagated distally, and mean propagation distance was shortened; and (5) intestinal transit was slower for solids, but not for liquids. In the small intestine, extrinsic nerves modulate motor activity, which is under primary control of the intrinsic (enteric) nervous system.

Author List

Johnson CP, Sarna SK, Cowles VE, Osborn JL, Zhu YR, Bonham L, Buchmann E, Baytiyeh R, Telford GL, Roza AM

Authors

Christopher P. Johnson MD Professor in the Surgery department at Medical College of Wisconsin
Allan M. Roza MD Professor in the Surgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Autonomic Denervation
Autonomic Nervous System
Dogs
Enteric Nervous System
Fasting
Female
Food
Gastrointestinal Transit
Jejunum
Male
Myoelectric Complex, Migrating
jenkins-FCD Prod-478 d1509cf07a111124a2d122fd3df854cc0b993c00