Redox status of dogs with non-hodgkin lymphomas. An ESR study. Cancer Lett 2005 Jun 28;224(2):339-46
Date
05/26/2005Pubmed ID
15914284DOI
10.1016/j.canlet.2004.11.037Scopus ID
2-s2.0-19444383995 (requires institutional sign-in at Scopus site) 18 CitationsAbstract
Free radical and antioxidant parameters in healthy dogs (n=10) and dogs with non-Hodgkin lymphomas (n=11) were measured in blood and lymph node tissue samples before chemotherapy. Enzymatic and other biochemical measurements were performed. We found that (i) free radical concentrations based on ESR spectra of tissues correlated with higher proliferative character; (ii) lymphoma cases showed an impaired antioxidant status; (iii) tumors with low oxidative burst capacity and higher reduced/oxidized glutathione ratio responded better to chemotherapy; and (iv) affected blood and lymph nodes were under strong oxidative stress.
Author List
Vajdovich P, Kriska T, Mézes M, Szabó PR, Balogh N, Bánfi A, Arany-Tóth A, Gaál T, Jakus JAuthor
Tamas Kriska PhD Research Scientist I in the Pharmacology and Toxicology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAntioxidants
Cell Proliferation
Dog Diseases
Dogs
Female
Free Radicals
Lymphoma, Non-Hodgkin
Male
Oxidative Stress
Spectrum Analysis
