[Epidermal growth factor with insulin used for stimulation of exogenous colony formation in the spleen of mice irradiated with lethal doses of X-rays]. Tsitologiia 1988 Jan;30(1):58-61
Date
01/01/1988Pubmed ID
3282372Scopus ID
2-s2.0-0023871965 (requires institutional sign-in at Scopus site)Abstract
Epidermal growth factor (12 ng per 1 g of body mass) and insulin (0.004 units per 1 g of body mass) were introduced into X-ray irradiated (1.8, 2.12, 2.7 Cr) mice. Four hours later bone marrow was extracted from femurs to be introduced into syngenic lethally irradiated recipients. On the 11th day after transplantation the number of exogenic spleen colonies was computed. The epidermal growth factor, in combination with insulin, stimulates in the organism the restoration of hemopoietic colony-forming cells after radiation injury.
Author List
Gracheva NI, Zhestianikov VD, Bil'din VN, Pereverzev AE, Sorokin ABAuthor
Andrey Sorokin PhD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBone Marrow Transplantation
Colony-Forming Units Assay
Epidermal Growth Factor
Hematopoietic Stem Cells
Insulin
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Spleen
Stimulation, Chemical
Time Factors
Transplantation, Isogeneic
