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Feedback inhibition of adrenocorticotropin and vasopressin responses to hypoxia by physiological increases in endogenous plasma corticosteroids in dogs. Endocrinology 1984 Apr;114(4):1245-9

Date

04/01/1984

Pubmed ID

6323137

DOI

10.1210/endo-114-4-1245

Scopus ID

2-s2.0-0021243181   20 Citations

Abstract

We examined the influence of increases in plasma corticosteroids produced by ACTH infusion on subsequent ACTH and vasopressin (AVP) responses to hypoxia in anesthetized dogs. Basal and stimulated ACTH levels were inhibited by increases in corticosteroids. Moderate increases in corticosteroids (5.2 micrograms/dl) caused a 50% reduction in the subsequent integrated ACTH response to hypoxia. Maximal increases in corticosteroids eliminated the integrated ACTH response to hypoxia. In addition, AVP responses to hypoxia were attenuated by prior maximal elevations in corticosteroids. Physiological elevation of corticosteroids inhibits subsequent ACTH and AVP responses to hypoxia.

Author List

Raff H, Shinsako J, Keil LC, Dallman MF

Author

Hershel Raff PhD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adrenal Cortex Hormones
Adrenocorticotropic Hormone
Animals
Arginine Vasopressin
Blood Gas Analysis
Cosyntropin
Dogs
Female
Hydrogen-Ion Concentration
Hypoxia
Kinetics
Male
Oxygen
Partial Pressure
jenkins-FCD Prod-484 8aa07fc50b7f6d102f3dda2f4c7056ff84294d1d