Feedback inhibition of adrenocorticotropin and vasopressin responses to hypoxia by physiological increases in endogenous plasma corticosteroids in dogs. Endocrinology 1984 Apr;114(4):1245-9
Date
04/01/1984Pubmed ID
6323137DOI
10.1210/endo-114-4-1245Scopus ID
2-s2.0-0021243181 (requires institutional sign-in at Scopus site) 20 CitationsAbstract
We examined the influence of increases in plasma corticosteroids produced by ACTH infusion on subsequent ACTH and vasopressin (AVP) responses to hypoxia in anesthetized dogs. Basal and stimulated ACTH levels were inhibited by increases in corticosteroids. Moderate increases in corticosteroids (5.2 micrograms/dl) caused a 50% reduction in the subsequent integrated ACTH response to hypoxia. Maximal increases in corticosteroids eliminated the integrated ACTH response to hypoxia. In addition, AVP responses to hypoxia were attenuated by prior maximal elevations in corticosteroids. Physiological elevation of corticosteroids inhibits subsequent ACTH and AVP responses to hypoxia.
Author List
Raff H, Shinsako J, Keil LC, Dallman MFAuthor
Hershel Raff PhD Professor in the Academic Affairs department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Adrenal Cortex HormonesAdrenocorticotropic Hormone
Animals
Arginine Vasopressin
Blood Gas Analysis
Cosyntropin
Dogs
Female
Hydrogen-Ion Concentration
Hypoxia
Kinetics
Male
Oxygen
Partial Pressure