Maternal Western diet increases adiposity even in male offspring of obesity-resistant rat dams: early endocrine risk markers. Am J Physiol Regul Integr Comp Physiol 2016 Dec 01;311(6):R1045-R1059
Date
09/23/2016Pubmed ID
27654396Pubmed Central ID
PMC5256983DOI
10.1152/ajpregu.00023.2016Scopus ID
2-s2.0-85002672104 (requires institutional sign-in at Scopus site) 26 CitationsAbstract
Maternal overnutrition or associated complications putatively mediate the obesogenic effects of perinatal high-fat diet on developing offspring. Here, we tested the hypothesis that a Western diet developmental environment increases adiposity not only in male offspring from obesity-prone (DIO) mothers, but also in those from obesity-resistant (DR) dams, implicating a deleterious role for the Western diet per se. Selectively bred DIO and DR female rats were fed chow (17% kcal fat) or Western diet (32%) for 54 days before mating and, thereafter, through weaning. As intended, despite chow-like caloric intake, Western diet increased prepregnancy weight gain and circulating leptin levels in DIO, but not DR, dams. Yet, in both genotypes, maternal Western diet increased the weight and adiposity of preweanlings, as early as in DR offspring, and increased plasma leptin, insulin, and adiponectin of weanlings. Although body weight normalized with chow feeding during adolescence, young adult Western diet offspring subsequently showed decreased energy expenditure and, in DR offspring, decreased lipid utilization as a fuel substrate. By mid-adulthood, maternal Western diet DR offspring ate more chow, weighed more, and were fatter than controls. Thus, maternal Western diet covertly programmed increased adiposity in childhood and adulthood, disrupted relations of energy regulatory hormones with body fat, and decreased energy expenditure in offspring of lean, genetically obesity-resistant mothers. Maternal Western diet exposure alone, without maternal obesity or overnutrition, can promote offspring weight gain.
Author List
Frihauf JB, Fekete ÉM, Nagy TR, Levin BE, Zorrilla EPAuthor
Eva M. Fekete PhD Research Scientist I in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdiposityAnimals
Animals, Outbred Strains
Biomarkers
Diet, Western
Disease Resistance
Energy Intake
Female
Hormones
Male
Maternal Nutritional Physiological Phenomena
Obesity
Pregnancy
Prenatal Exposure Delayed Effects
Rats
Rats, Sprague-Dawley
Risk Factors
