Faculty Collaboration Database

Bombesin injection into the central amygdala influences feeding behavior in the rat. Peptides 1999;20(4):437-44

Date

08/24/1999

Pubmed ID

10458512

DOI

10.1016/s0196-9781(99)00023-6

Scopus ID

2-s2.0-0345151813 (requires institutional sign-in at Scopus site)   13 Citations

Abstract

The present study was performed to determine whether low doses (10 or 40 ng) of bombesin microinjected into the amygdala could modify solid food intake. Forty ng of bombesin in 24 h deprived rats caused transient inhibition of food intake. This inhibitory effect was eliminated by prior bombesin antagonist treatment. A series of quantitative behavioral tests indicated that low doses of bombesin application specifically reduced food intake without altering the behavioral pattern or influencing the body temperature. The present results suggest, that bombesin-like peptides may act as a satiety signal in the central part of the amygdala.

Author List

Vígh J, Lénárd L, Fekete E, Hernádi I

Author

Eva M. Fekete PhD Research Scientist I in the Physiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Amygdala
Animals
Body Temperature
Bombesin
Dose-Response Relationship, Drug
Feeding Behavior
Food Deprivation
Male
Rats