Bombesin microinjection into the basolateral amygdala influences feeding behavior in the rat. Brain Res 1999 Nov 20;847(2):253-61
Date
11/27/1999Pubmed ID
10575095DOI
10.1016/s0006-8993(99)02057-0Scopus ID
2-s2.0-0344031623 (requires institutional sign-in at Scopus site) 10 CitationsAbstract
It has been demonstrated that the basolateral amygdala (ABL) represents a satiety mechanism. Experimental data indicate that peripheral or central applications of neuropeptide bombesin (BN) and BN-like peptides inhibit feeding. Since the amygdala (AMY) is rich in BN-like immunoreactive elements, the present study was performed to determine whether 10 or 40 ng doses of BN microinjected bilaterally into the ABL could modify solid food intake. Twenty nanograms of BN (10 ng per injection site) in 24-h deprived rats caused transient inhibition of food intake and 80 ng resulted in a significant reduction of food consumption for 1 h. This inhibitory effect of BN on feeding was eliminated by prior BN antagonist treatment. Results of behavioral tests showed that BN microinjections into the ABL specifically reduced food intake without altering behavioral patterns or influencing the body temperature. Present results suggest that BN-like peptides may act as a complex satiety signal in the ABL.
Author List
Vígh J, Lénárd L, Fekete EAuthor
Eva M. Fekete PhD Research Scientist I in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AmygdalaAnimals
Body Temperature
Bombesin
Eating
Feeding Behavior
Male
Microinjections
Rats
