The Behavioral Phenotype of 7q11.23 Duplication Syndrome Includes Risk for Oppositional Behavior and Aggression. J Dev Behav Pediatr 2022 Aug 01;43(6):e390-e398
Date
05/18/2022Pubmed ID
35580312Pubmed Central ID
PMC9329151DOI
10.1097/DBP.0000000000001068Scopus ID
2-s2.0-85131423558 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
OBJECTIVE: 7q11.23 duplication syndrome (Dup7) is a genetic disorder with a variable phenotype associated with cognitive and behavioral characteristics including a high incidence of expressive language difficulties, social anxiety, and oppositional or disruptive behavior. Correlates of aggression and oppositionality were examined.
METHOD: Participants were 63 children with genetically confirmed Dup7 between the ages of 4 and 17 years. A multimethod, multi-informant approach was used to assess aggression and oppositional behavior, and the contributions of cognitive functioning, expressive language, autism spectrum, social anxiety, and hyperactivity/impulsivity (H/I) symptomatology were considered.
RESULTS: Elevated levels of aggression and oppositional behavior were found. Cognitive functioning, expressive language, and autism spectrum disorder symptomatology were not significantly related to parent ratings of aggression, although young children who had language and nonverbal cognitive delays were most likely to demonstrate examiner-observed aggression. Social anxiety and H/I symptomatology were related to defiant/aggressive and oppositional behavior.
CONCLUSION: Genes in the 7q11.23 region duplicated in Dup7, in transaction with the environment, may contribute to aggressive and oppositional behavior.
Author List
Klein-Tasman BP, Yund BD, Mervis CBAuthor
Bonita Klein-Tasman BA,MA,PhD Professor in the Psychology department at University of Wisconsin - MilwaukeeMESH terms used to index this publication - Major topics in bold
AggressionAttention Deficit Disorder with Hyperactivity
Attention Deficit and Disruptive Behavior Disorders
Autism Spectrum Disorder
Humans
Phenotype
Problem Behavior
