Renin, ACTH, and adrenocortical function during hypoxia and hemorrhage in conscious rats. Am J Physiol 1986 Feb;250(2 Pt 2):R240-4
Date
02/01/1986Pubmed ID
3004236DOI
10.1152/ajpregu.1986.250.2.R240Scopus ID
2-s2.0-0022447148 (requires institutional sign-in at Scopus site) 47 CitationsAbstract
We studied the effect of chronic hypoxia on the renin, adrenocorticotropin (ACTH), aldosterone, and corticosterone responses to acute hemorrhage in conscious male rats with chronic femoral arterial catheters. Rats were exposed to 21, 12.5, or 10% O2 (n = 7 per group). At 42 h of exposure, animals underwent a rapid 6 ml/kg hemorrhage. O2 at 12.5 and 10% led to significant hypoxemia (arterial PO2 = 52 +/- 1 and 43 +/- 1 Torr, respectively) and respiratory alkalosis. Significant increases in plasma sodium to 145 +/- 2 meq/l and decreases in plasma potassium to 3.53 +/- 0.12 meq/l were also observed during hypoxia. Hypoxia per se had no significant effect on blood pressure, plasma renin activity, ACTH, and corticosterone. O2 at 12.5% led to a significant reduction in aldosterone levels (0.9 +/- 0.8 ng/dl) compared with normoxia (4.2 +/- 0.9 ng/dl). The mean arterial pressure, plasma renin activity, and aldosterone responses to hemorrhage were unaltered by hypoxia. ACTH and corticosterone responses to hemorrhage were potentiated by exposure to 10% O2. We conclude that chronic exposure to severe hypoxia augments the pituitary-adrenal but not the renin-aldosterone response to hemorrhage.
Author List
Raff H, Sandri RB, Segerson TPAuthor
Hershel Raff PhD Professor in the Academic Affairs department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Adrenal CortexAdrenocorticotropic Hormone
Aldosterone
Analysis of Variance
Animals
Blood Gas Analysis
Blood Pressure
Corticosterone
Electrolytes
Hemorrhage
Hypoxia
Male
Rats
Renin
