Faculty Collaboration Database

Renin, ACTH, and adrenocortical function during hypoxia and hemorrhage in conscious rats. Am J Physiol 1986 Feb;250(2 Pt 2):R240-4

Date

02/01/1986

Pubmed ID

3004236

DOI

10.1152/ajpregu.1986.250.2.R240

Scopus ID

2-s2.0-0022447148   45 Citations

Abstract

We studied the effect of chronic hypoxia on the renin, adrenocorticotropin (ACTH), aldosterone, and corticosterone responses to acute hemorrhage in conscious male rats with chronic femoral arterial catheters. Rats were exposed to 21, 12.5, or 10% O2 (n = 7 per group). At 42 h of exposure, animals underwent a rapid 6 ml/kg hemorrhage. O2 at 12.5 and 10% led to significant hypoxemia (arterial PO2 = 52 +/- 1 and 43 +/- 1 Torr, respectively) and respiratory alkalosis. Significant increases in plasma sodium to 145 +/- 2 meq/l and decreases in plasma potassium to 3.53 +/- 0.12 meq/l were also observed during hypoxia. Hypoxia per se had no significant effect on blood pressure, plasma renin activity, ACTH, and corticosterone. O2 at 12.5% led to a significant reduction in aldosterone levels (0.9 +/- 0.8 ng/dl) compared with normoxia (4.2 +/- 0.9 ng/dl). The mean arterial pressure, plasma renin activity, and aldosterone responses to hemorrhage were unaltered by hypoxia. ACTH and corticosterone responses to hemorrhage were potentiated by exposure to 10% O2. We conclude that chronic exposure to severe hypoxia augments the pituitary-adrenal but not the renin-aldosterone response to hemorrhage.

Author List

Raff H, Sandri RB, Segerson TP

Author

Hershel Raff PhD Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adrenal Cortex
Adrenocorticotropic Hormone
Aldosterone
Analysis of Variance
Animals
Blood Gas Analysis
Blood Pressure
Corticosterone
Electrolytes
Hemorrhage
Hypoxia
Male
Rats
Renin