Acute volume expansion decreases adrenocortical sensitivity to ACTH and angiotensin II. Am J Physiol 1985 Nov;249(5 Pt 2):R611-6
Date
11/01/1985Pubmed ID
2998212DOI
10.1152/ajpregu.1985.249.5.R611Scopus ID
2-s2.0-17744407700 (requires institutional sign-in at Scopus site) 11 CitationsAbstract
This study examined the plasma aldosterone and corticosteroid responses to a 60-min infusion of adrenocorticotropin (ACTH) or angiotensin (ANG) II started immediately after an acute isotonic saline volume expansion (0.5 ml . kg-1 . min-1 for 30 min). Five conscious dogs of either sex with exteriorized carotid loops were used in this repeated-design study. Volume expansion per se caused a 10% decrease in hematocrit, a 12.5% decrease in plasma protein, and a 2.7-mmHg increase in central venous pressure with no change in mean arterial pressure, heart rate, or plasma sodium. Volume expansion per se also resulted in significant reductions in vasopressin, plasma renin activity, ACTH, aldosterone, and corticosteroid levels. The aldosterone responses to ACTH and ANG II were significantly inhibited (46-71%) by acute volume expansion. The corticosteroid response to ACTH was 19-29% inhibited by volume expansion. We conclude that acute volume expansion significantly inhibits the adrenocortical sensitivity to its tropic hormones probably via alterations of synergistic factors.
Author List
Raff H, Shinsako J, Wade CE, Keil LC, Dallman MFAuthor
Hershel Raff PhD Professor in the Academic Affairs department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Adrenal CortexAdrenocorticotropic Hormone
Angiotensin II
Animals
Blood Volume
Dogs
Drug Resistance
Female
Male
Sodium Chloride
Time Factors