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Adrenocortical function after acute carbon monoxide exposure in humans. Arch Environ Health 1985 Mar-Apr;40(2):88-90

Date

03/01/1985

Pubmed ID

2988463

DOI

10.1080/00039896.1985.10545895

Scopus ID

2-s2.0-0021839869   11 Citations

Abstract

The effect of acute carbon monoxide (CO) exposure on plasma adrenocorticotrophic hormone (ACTH), renin activity (PRA), aldosterone, and cortisol levels was studied in patients approximately 80-90 min after removal from the scene of exposure. Nine patients had carboxyhemoglobin (COHb) levels below 15%. Seven patients had COHb levels that exceeded 15% (Group II). Plasma ACTH, cortisol, and aldosterone levels were significantly higher in Group II (elevated COHb). Plasma cortisol and aldosterone levels were appropriate for the levels of ACTH and PRA achieved. We concluded that (a) acute carbon monoxide poisoning leads to elevated plasma corticosteroid levels, and (b) the adrenal gland appears to function normally acutely after exposure to carbon monoxide.

Author List

Raff H, Goldmann RW, Kindwall EP

Author

Hershel Raff PhD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Adrenal Glands
Adrenocorticotropic Hormone
Adult
Aged
Aldosterone
Blood Gas Analysis
Carbon Monoxide
Carbon Monoxide Poisoning
Carboxyhemoglobin
Child
Child, Preschool
Female
Humans
Hydrocortisone
Hydrogen-Ion Concentration
Infant
Male
Middle Aged
Radioimmunoassay
Renin
jenkins-FCD Prod-484 8aa07fc50b7f6d102f3dda2f4c7056ff84294d1d