Adrenocortical function after acute carbon monoxide exposure in humans. Arch Environ Health 1985;40(2):88-90
Date
03/01/1985Pubmed ID
2988463DOI
10.1080/00039896.1985.10545895Scopus ID
2-s2.0-0021839869 (requires institutional sign-in at Scopus site) 12 CitationsAbstract
The effect of acute carbon monoxide (CO) exposure on plasma adrenocorticotrophic hormone (ACTH), renin activity (PRA), aldosterone, and cortisol levels was studied in patients approximately 80-90 min after removal from the scene of exposure. Nine patients had carboxyhemoglobin (COHb) levels below 15%. Seven patients had COHb levels that exceeded 15% (Group II). Plasma ACTH, cortisol, and aldosterone levels were significantly higher in Group II (elevated COHb). Plasma cortisol and aldosterone levels were appropriate for the levels of ACTH and PRA achieved. We concluded that (a) acute carbon monoxide poisoning leads to elevated plasma corticosteroid levels, and (b) the adrenal gland appears to function normally acutely after exposure to carbon monoxide.
Author List
Raff H, Goldmann RW, Kindwall EPAuthor
Hershel Raff PhD Professor in the Academic Affairs department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdrenal Glands
Adrenocorticotropic Hormone
Adult
Aged
Aldosterone
Blood Gas Analysis
Carbon Monoxide
Carbon Monoxide Poisoning
Carboxyhemoglobin
Child
Child, Preschool
Female
Humans
Hydrocortisone
Hydrogen-Ion Concentration
Infant
Male
Middle Aged
Radioimmunoassay
Renin
