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Testosterone-Mediated Aggression in Angelman Syndrome Treated With Leuprolide and Orchiectomy. Cureus 2022 May;14(5):e24865

Date

06/15/2022

Pubmed ID

35698716

Pubmed Central ID

PMC9184178

DOI

10.7759/cureus.24865

Abstract

Angelman syndrome (AS) is a rare genetic imprinting disorder characterized by a maternal microdeletion of the 15q11q13 locus. It is traditionally associated with intellectual disability, inappropriate laughing, and a happy demeanor. Here, we report a patient with AS who presented with aggression and hypersexuality and was successfully treated with leuprolide injections for nine years until a definitive orchiectomy was performed. To the best of our knowledge, this is the first report of castration as a treatment for refractory behavioral symptoms in a patient with AS.

Author List

Anderson DJ, Porwal MH, Sandlow JI

Author

Jay I. Sandlow MD Chair, Professor in the Urologic Surgery department at Medical College of Wisconsin