Testosterone-Mediated Aggression in Angelman Syndrome Treated With Leuprolide and Orchiectomy. Cureus 2022 May;14(5):e24865
Date
06/15/2022Pubmed ID
35698716Pubmed Central ID
PMC9184178DOI
10.7759/cureus.24865Abstract
Angelman syndrome (AS) is a rare genetic imprinting disorder characterized by a maternal microdeletion of the 15q11q13 locus. It is traditionally associated with intellectual disability, inappropriate laughing, and a happy demeanor. Here, we report a patient with AS who presented with aggression and hypersexuality and was successfully treated with leuprolide injections for nine years until a definitive orchiectomy was performed. To the best of our knowledge, this is the first report of castration as a treatment for refractory behavioral symptoms in a patient with AS.