Surgical outcomes and survival of adrenocortical carcinoma between children and adults. Am J Surg 2022 Oct;224(4):1090-1094
Date
06/11/2022Pubmed ID
35688671Pubmed Central ID
PMC10276358DOI
10.1016/j.amjsurg.2022.05.033Scopus ID
2-s2.0-85131825408 (requires institutional sign-in at Scopus site) 5 CitationsAbstract
INTRODUCTION: Adrenocortical carcinoma (ACC) is associated with poor outcomes. We compared surgical outcomes between children and adult; and identified factors independently associated with survival.
METHODS: Using the National Cancer Database, children and adults with ACC who underwent surgery between 2004 and 2016 were identified. We compared outcomes and survival between groups. Cox regression analysis was performed to identify predictors of survival.
RESULTS: Of 2553 patients, 2.8% were children. A higher proportion of children were Hispanic (19.1%vs.6.6%) and covered by government insurance (45.1%vs.35.8%) than adults. More pediatric patients received lymphadenectomy and chemotherapy than adults. Pediatric patients had better survival at 1 -(91.4%; 95%CI: 81.2%-96.0% vs.79.6%; 95%CI: 77.9%-81.1%) and 5-years (60.6%; 95%CI:47.5%-71.3% vs.44.9%; 95%CI 42.7%- 47.0) (p = 0.0016). Age≥18 (HR: 2.21(1.50-3.27)), metastatic disease at diagnosis (HR: 3.51(3.04-4.04)), and receipt of lymphadenectomy (HR: 1.30(1.14-1.48)) were independently associated with worse survival.
CONCLUSIONS: Children with ACC had better survival than adults. Factors independently associated with worse survival included older age, metastatic disease, and receipt of lymph node surgery.
Author List
Akinkuotu AC, Peace A, Maduekwe UN, Hayes AAAuthor
Ugwuji N. Maduekwe MD Associate Dean, Associate Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdrenal Cortex Neoplasms
Adrenocortical Carcinoma
Adult
Child
Humans
Lymph Node Excision
Retrospective Studies
Treatment Outcome
