Structural Models for Roseolovirus U20 And U21: Non-Classical MHC-I Like Proteins From HHV-6A, HHV-6B, and HHV-7. Front Immunol 2022;13:864898
Date
04/22/2022Pubmed ID
35444636Pubmed Central ID
PMC9013968DOI
10.3389/fimmu.2022.864898Scopus ID
2-s2.0-85128490952 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
Human roseolovirus U20 and U21 are type I membrane glycoproteins that have been implicated in immune evasion by interfering with recognition of classical and non-classical MHC proteins. U20 and U21 are predicted to be type I glycoproteins with extracytosolic immunoglobulin-like domains, but detailed structural information is lacking. AlphaFold and RoseTTAfold are next generation machine-learning-based prediction engines that recently have revolutionized the field of computational three-dimensional protein structure prediction. Here, we review the structural biology of viral immunoevasins and the current status of computational structure prediction algorithms. We use these computational tools to generate structural models for U20 and U21 proteins, which are predicted to adopt MHC-Ia-like folds with closed MHC platforms and immunoglobulin-like domains. We evaluate these structural models and place them within current understanding of the structural basis for viral immune evasion of T cell and natural killer cell recognition.
Author List
Weaver GC, Arya R, Schneider CL, Hudson AW, Stern LJAuthor
Amy W. Hudson PhD Professor in the Microbiology and Immunology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Herpesvirus 6, HumanHerpesvirus 7, Human
Humans
Models, Structural
Roseolovirus Infections
Viral Proteins
