Faculty Collaboration Database

Determinants of intrabolus pressure during esophageal peristaltic bolus transport. Am J Physiol 1993 Mar;264(3 Pt 1):G407-13

Date

03/01/1993

Pubmed ID

8460696

DOI

10.1152/ajpgi.1993.264.3.G407

Scopus ID

2-s2.0-0027401191 (requires institutional sign-in at Scopus site)   78 Citations

Abstract

Previous manometric studies of esophageal fluid bolus transport in humans have generally ignored the hydrodynamic distinction between intrabolus pressure and pressure within the lumen-occluded, contracting esophageal segment. In this study we obtained concurrent esophageal videofluoroscopic and intraluminal manometric recordings in supine normal volunteers using different bolus volumes and viscosities and abdominal compression. Intrabolus pressure increased with bolus volume, viscosity, and abdominal compression. Esophageal diameter increased with larger bolus volumes, and this increase was correlated with increases in intrabolus pressure. Intrabolus pressure was highest in the bolus tail. Peak intraluminal pressures > 20 mmHg above basal intrabolus pressure almost invariably were associated with effective peristalsis, whereas values of this pressure differential < 20 mmHg frequently were associated with ineffective peristalsis and retrograde bolus escape. Intrabolus pressure can serve as an important indicator of the forces resisting peristaltic transport and the occurrence of ineffective bolus transport.

Author List

Ren J, Massey BT, Dodds WJ, Kern MK, Brasseur JG, Shaker R, Harrington SS, Hogan WJ, Arndorfer RC

Authors

Mark K. Kern Research Scientist II in the Medicine department at Medical College of Wisconsin
Benson T. Massey MD Professor in the Medicine department at Medical College of Wisconsin
Reza Shaker MD Assoc Provost, Sr Assoc Dean, Ctr Dir, Chief, Prof in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Abdomen
Adult
Analysis of Variance
Biomechanical Phenomena
Deglutition
Esophagus
Fluoroscopy
Humans
Male
Manometry
Middle Aged
Models, Biological
Peristalsis
Video Recording