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Postprandial motor activity and its relationship to transit in the canine ileum. Surgery 1997 Feb;121(2):182-9

Date

02/01/1997

Pubmed ID

9037230

DOI

10.1016/s0039-6060(97)90288-9

Scopus ID

2-s2.0-0031059019   14 Citations

Abstract

BACKGROUND: The purpose of this study was to elucidate the mechanism of reduced intestinal transit rate in the ileum as compared with the jejunum.

METHODS: Twenty-one dogs were each instrumented with 12 strain gauge transducers, 2 collection cannulas, and an infusion catheter defining a 100 cm study in the midjejunum (n = 11) and midileum (n = 10). Postprandial motor activity and intestinal transit were measured 1 hour after ingestion of a 650 kcal solid meal. Contractile activity was analyzed by means of computer programs that determine frequency, amplitude, and propagation behavior of circular smooth muscle contractions.

RESULTS: Postprandial ileal contractions occurred with greater frequency (13.7 +/- 2.5 versus 11.5 +/- 0.4; p = 0.04) and displayed a higher incidence of propagation (61% +/- 2% versus 44% +/- 3%; p = 0.0001) than jejunal contractions, but traveled at significantly slower rates (1.0 +/- 0.7 cm/sec vs 3.7 +/- 0.9 cm/sec; p = 0.0001). The net result was significantly slower transit in the ileum compared with the jejunum (4.7 +/- 0.7 cm/min versus 13.1 +/- 1.5 cm/min; p = 0.0006). Within each region, transit correlated with parameters of propagating contractions. Stepwise regression of the combined data revealed that contraction velocity was the most important variable determining intestinal transit rate (r = 0.64; p < 0.001).

CONCLUSIONS: Contrary to previous thinking, postprandial ileal contractions display a high degree of temporal and spatial organization. Slow ileal transit is mainly due to reduced propagation velocity, which is intrinsic to the circular smooth muscle.

Author List

Johnson CP, Sarna SK, Baytiyeh R, Zhu YR, Cowles VE, Telford GL, Roza AM, Adams MB

Authors

Christopher P. Johnson MD Professor in the Surgery department at Medical College of Wisconsin
Allan M. Roza MD Professor in the Surgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Dogs
Fasting
Female
Gastrointestinal Motility
Ileum
In Vitro Techniques
Jejunum
Male
Muscle Contraction
Postprandial Period
jenkins-FCD Prod-478 d1509cf07a111124a2d122fd3df854cc0b993c00