Semantic network activation facilitates oral word reading in chronic aphasia. Brain Lang 2022 Oct;233:105164
Date
08/08/2022Pubmed ID
35933744Pubmed Central ID
PMC9948519DOI
10.1016/j.bandl.2022.105164Scopus ID
2-s2.0-85135407900 (requires institutional sign-in at Scopus site)Abstract
People with aphasia often show partial impairments on a given task. This trial-to-trial variability offers a potential window into understanding how damaged language networks function. We test the hypothesis that successful word reading in participants with phonological system damage reflects semantic system recruitment. Residual semantic and phonological networks were defined with fMRI in 21 stroke participants with phonological damage using semantic- and rhyme-matching tasks. Participants performed an oral word reading task, and activation was compared between correct and incorrect trials within the semantic and phonological networks. The results showed a significant interaction between hemisphere, network activation, and reading success. Activation in the left hemisphere semantic network was higher when participants successfully read words. Residual phonological regions showed no difference in activation between correct and incorrect trials on the word reading task. The results provide evidence that semantic processing supports successful phonological retrieval in participants with phonological impairment.
Author List
Pillay SB, Gross WL, Heffernan J, Book DS, Binder JRAuthors
Jeffrey R. Binder MD Professor in the Neurology department at Medical College of WisconsinDiane S. Book MD Associate Professor in the Neurology department at Medical College of Wisconsin
William Gross MD, PhD Assistant Professor in the Anesthesiology department at Medical College of Wisconsin
Sara B. Pillay PhD Assistant Professor in the Neurology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AphasiaHumans
Magnetic Resonance Imaging
Reading
Semantic Web
Semantics
