Faculty Collaboration Database

Reduction of physiological fluctuations in fMRI using digital filters. Magn Reson Med 1996 Jan;35(1):107-13

Date

01/01/1996

Pubmed ID

8771028

DOI

10.1002/mrm.1910350114

Scopus ID

2-s2.0-0030053163 (requires institutional sign-in at Scopus site)   262 Citations

Abstract

Data obtained from functional magnetic resonance imaging are often limited by a low signal-to-noise ratio. The time-course data obtained from activated regions contain both system noise and physiological noise, primarily linked to the heart and respiratory rates, that are superimposed on task induced signals. Time averaging of a practical number of data sets is not very effective in improving the signal-to-noise ratio because neither system nor physiological noise is truly random. In this paper, a method is presented for filtering unwanted physiological fluctuations, including aliased signals that are formed as a result of long repetition time (TR) values. A pulse oximeter was used to obtain cardiac and respiratory information during the scanning period. Finite impulse response band-reject digital filters were designed to remove the physiological fluctuations. For comparison, cross-correlation analyses were performed at the same level of statistical significance on both filtered and unfiltered data. We demonstrate that this method can improve the detection of weak signals without increasing the probability of false positives.

Author List

Biswal B, DeYoe EA, Hyde JS

Author

Edgar A. DeYoe PhD Adjunct Professor in the Radiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Artifacts
Brain
Brain Mapping
Female
Filtration
Fourier Analysis
Heart Rate
Humans
Magnetic Resonance Imaging
Male
Models, Anatomic
Regional Blood Flow
Respiration
Signal Processing, Computer-Assisted