Faculty Collaboration Database

Redefining risk in acute coronary syndromes using molecular medicine. J Am Coll Cardiol 2007 Jan 23;49(3):279-89

Date

01/24/2007

Pubmed ID

17239708

DOI

10.1016/j.jacc.2006.08.051

Scopus ID

2-s2.0-33846262006 (requires institutional sign-in at Scopus site)   29 Citations

Abstract

Acute coronary syndromes represent a complex phenotype involving the interplay of many elements. The risk of developing an acute coronary syndrome and related complications has been defined by variables such as age, diabetes, smoking history, serum creatine phosphokinase, or electrocardiographic findings. However, in the past 5 years the wide-scale acceptance of a protein--troponin--has changed the diagnostic profile. With advances in molecular medicine, this protein is a segue to a panel of molecular assays that will improve screening and tailored intervention. We expound upon some of these factors and the potential they may carry in changing clinical medicine.

Author List

Anwaruddin S, Askari AT, Topol EJ

Author

Saif Anwaruddin MD Associate Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Angina, Unstable
C-Reactive Protein
CD40 Ligand
Female
Genetic Markers
Genetic Predisposition to Disease
Humans
Male
Molecular Biology
Myocardial Infarction
Myocardial Revascularization
P-Selectin
Prognosis
Risk Assessment
Sensitivity and Specificity
Troponin T