Faculty Collaboration Database

Folic acid supplementation improves vascular function in amenorrheic runners. Clin J Sport Med 2010 May;20(3):205-10

Date

05/07/2010

Pubmed ID

20445362

DOI

10.1097/JSM.0b013e3181df59f4

Scopus ID

2-s2.0-77952002337 (requires institutional sign-in at Scopus site)   28 Citations

Abstract

OBJECTIVE: The purpose of this study was to determine if folic acid supplementation improves endothelial vascular function (brachial artery flow-mediated dilation; FMD) in amenorrheic runners.

DESIGN: Prospective cross-sectional study.

SETTING: Academic medical center in the Midwest.

PARTICIPANTS: Ten amenorrheic and 10 eumenorrheic women runners from the community volunteered for this study.

INTERVENTIONS: Each participant was treated with folic acid (10 mg/d) for 4 weeks.

MAIN OUTCOME MEASURES: Brachial artery FMD was measured before and after folic acid supplementation with standard techniques.

RESULTS: The brachial artery FMD response to reactive hyperemia improved after folic acid supplementation in amenorrheic women (3.0% +/- 2.3% vs. 7.7% +/- 4.5%; P = 0.02). In the eumenorrheic control group, there was no change in brachial artery FMD (6.7% +/- 2.0% vs. 5.9% +/- 2.6%; P = 0.52).

CONCLUSIONS: This study demonstrates that brachial artery FMD, an indicator of vascular endothelial function, improves in amenorrheic female runners after short-term supplementation with folic acid.

Author List

Hoch AZ, Lynch SL, Jurva JW, Schimke JE, Gutterman DD

MESH terms used to index this publication - Major topics in bold

Academic Medical Centers
Adult
Amenorrhea
Blood Flow Velocity
Brachial Artery
Cross-Sectional Studies
Dietary Supplements
Dilatation
Female
Folic Acid
Humans
Midwestern United States
Running
Young Adult