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Folic acid supplementation improves vascular function in amenorrheic runners. Clin J Sport Med 2010 May;20(3):205-10

Date

05/07/2010

Pubmed ID

20445362

DOI

10.1097/JSM.0b013e3181df59f4

Abstract

OBJECTIVE: The purpose of this study was to determine if folic acid supplementation improves endothelial vascular function (brachial artery flow-mediated dilation; FMD) in amenorrheic runners.

DESIGN: Prospective cross-sectional study.

SETTING: Academic medical center in the Midwest.

PARTICIPANTS: Ten amenorrheic and 10 eumenorrheic women runners from the community volunteered for this study.

INTERVENTIONS: Each participant was treated with folic acid (10 mg/d) for 4 weeks.

MAIN OUTCOME MEASURES: Brachial artery FMD was measured before and after folic acid supplementation with standard techniques.

RESULTS: The brachial artery FMD response to reactive hyperemia improved after folic acid supplementation in amenorrheic women (3.0% +/- 2.3% vs. 7.7% +/- 4.5%; P = 0.02). In the eumenorrheic control group, there was no change in brachial artery FMD (6.7% +/- 2.0% vs. 5.9% +/- 2.6%; P = 0.52).

CONCLUSIONS: This study demonstrates that brachial artery FMD, an indicator of vascular endothelial function, improves in amenorrheic female runners after short-term supplementation with folic acid.

Author List

Hoch AZ, Lynch SL, Jurva JW, Schimke JE, Gutterman DD

Authors

David D. Gutterman MD Sr Associate Director, Professor in the Medicine department at Medical College of Wisconsin
Anne Hoch DO Professor in the Orthopaedic Surgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Academic Medical Centers
Adult
Amenorrhea
Blood Flow Velocity
Brachial Artery
Cross-Sectional Studies
Dietary Supplements
Dilatation
Female
Folic Acid
Humans
Midwestern United States
Running
Young Adult