Faculty Collaboration Database

Validation of an online replanning technique for prostate adaptive radiotherapy. Phys Med Biol 2011 Jun 21;56(12):3659-68

Date

05/26/2011

Pubmed ID

21610293

DOI

10.1088/0031-9155/56/12/013

Scopus ID

2-s2.0-79958090578 (requires institutional sign-in at Scopus site)   19 Citations

Abstract

We have previously developed an online adaptive replanning technique to rapidly adapt the original plan according to daily CT. This paper reports the quality assurance (QA) developments in its clinical implementation for prostate cancer patients. A series of pre-clinical validation tests were carried out to verify the overall accuracy and consistency of the online replanning procedure. These tests include (a) phantom measurements of 22 individual patient adaptive plans to verify their accuracy and deliverability and (b) efficiency and applicability of the online replanning process. A four-step QA procedure was established to ensure the safe and accurate delivery of an adaptive plan, including (1) offline phantom measurement of the original plan, (2) online independent monitor unit (MU) calculation for a redundancy check, (3) online verification of plan-data transfer using an in-house software and (4) offline validation of actually delivered beam parameters. The pre-clinical validations demonstrate that the newly implemented online replanning technique is dosimetrically accurate and practically efficient. The four-step QA procedure is capable of identifying possible errors in the process of online adaptive radiotherapy and to ensure the safe and accurate delivery of the adaptive plans. Based on the success of this work, the online replanning technique has been used in the clinic to correct for interfractional changes during the prostate radiation therapy.

Author List

Peng C, Chen G, Ahunbay E, Wang D, Lawton C, Li XA

Authors

Ergun Ahunbay PhD Professor in the Radiation Oncology department at Medical College of Wisconsin
Guang-Pei Chen PhD Associate Professor in the Radiation Oncology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Humans
Male
Online Systems
Phantoms, Imaging
Posture
Prostatic Neoplasms
Quality Control
Radiotherapy Planning, Computer-Assisted
Safety
Software
Tomography, X-Ray Computed