Nectin-1 (HveC) is expressed at high levels in neural subtypes that regulate radial migration of cortical and cerebellar neurons of the developing human and murine brain. J Neurovirol 2008 Apr;14(2):164-72
Date
04/30/2008Pubmed ID
18444088DOI
10.1080/13550280801898672Scopus ID
2-s2.0-42949167175 (requires institutional sign-in at Scopus site) 11 CitationsAbstract
Herpes simplex viruses (HSV) produce age-dependent encephalitis characterized by more severe involvement of the cerebral cortex in younger hosts. To elucidate the potential role of the major neural entry receptor of HSV, nectin-1, in age-dependent susceptibility of cortical neurons to viral encephalitis, the authors examined the anatomical distribution of the receptor protein in the developing human and mouse cerebral cortex, hippocampus, and cerebellum by immunohistochemistry. Nectin-1 is expressed at high levels in guiding cells (radial glial cells and Cajal-Retzius cells) that regulate radial migration of neurons in cortical lamination, at lower levels in migrating neurons, and at variable levels in the transient ventricular and marginal zones of the cerebral cortical wall. These results may have implications regarding the selective spatiotemporal tropism of HSV to specific neuronal populations, and for the better understanding of neurodevelopmental defects caused by fetal HSV infections.
Author List
Prandovszky E, Horváth S, Gellért L, Kovács SK, Janka Z, Toldi J, Shukla D, Vályi-Nagy TAuthor
Sandor K. Kovacs MD Assistant Professor in the Pathology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBrain
Cell Adhesion Molecules
Cell Movement
Cerebellum
Cerebral Cortex
Female
Ganglia
Humans
Mice
Nectins
Neuroglia
Neurons
