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Keratinocyte PIEZO1 modulates cutaneous mechanosensation. Elife 2022 Sep 02;11

Date

09/03/2022

Pubmed ID

36053009

Pubmed Central ID

PMC9512397

DOI

10.7554/eLife.65987

Scopus ID

2-s2.0-85139375441 (requires institutional sign-in at Scopus site)   4 Citations

Abstract

Epidermal keratinocytes mediate touch sensation by detecting and encoding tactile information to sensory neurons. However, the specific mechanotransducers that enable keratinocytes to respond to mechanical stimulation are unknown. Here, we found that the mechanically-gated ion channel PIEZO1 is a key keratinocyte mechanotransducer. Keratinocyte expression of PIEZO1 is critical for normal sensory afferent firing and behavioral responses to mechanical stimuli in mice.

Author List

Mikesell AR, Isaeva O, Moehring F, Sadler KE, Menzel AD, Stucky CL

Authors

Olena Isaeva PhD Assistant Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of Wisconsin
Cheryl L. Stucky PhD Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Ion Channels
Keratinocytes
Mechanotransduction, Cellular
Mice
Sensory Receptor Cells
Skin
Touch