Successful infusional 5-fluorouracil administration in a patient with vasospastic angina. Am Heart J Plus 2022 May;17
Date
09/03/2022Pubmed ID
36051246Pubmed Central ID
PMC9432777DOI
10.1016/j.ahjo.2022.100147Scopus ID
2-s2.0-85153852108 (requires institutional sign-in at Scopus site) 1 CitationAbstract
A 48-year-old female with metastatic colon adenocarcinoma and history of pre-existing coronary vasospasm with ventricular tachycardia (VT) successfully tolerated de novo 5-fluorouracil (5-FU) chemotherapy infusions with prophylactic administration and optimization of anti-spasm medications. 5-FU has been reported to produce severe cardiotoxic side effects, including coronary vasospasm, ventricular arrhythmias, and sudden cardiac death, and is not typically reported in individuals with pre-existing coronary vasospasm.
Author List
Tai S, Mohananey D, Griffiths C, Johnson B, Garg J, Ridolfi TJ, Lohr NL, Chakrabarti S, Brown SAAuthors
Divyanshu Mohananey MD Assistant Professor in the Medicine department at Medical College of WisconsinTimothy J. Ridolfi MD, MS, FACS Associate Professor in the Surgery department at Medical College of Wisconsin