Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Successful infusional 5-fluorouracil administration in a patient with vasospastic angina. Am Heart J Plus 2022 May;17

Date

09/03/2022

Pubmed ID

36051246

Pubmed Central ID

PMC9432777

DOI

10.1016/j.ahjo.2022.100147

Scopus ID

2-s2.0-85153852108 (requires institutional sign-in at Scopus site)   1 Citation

Abstract

A 48-year-old female with metastatic colon adenocarcinoma and history of pre-existing coronary vasospasm with ventricular tachycardia (VT) successfully tolerated de novo 5-fluorouracil (5-FU) chemotherapy infusions with prophylactic administration and optimization of anti-spasm medications. 5-FU has been reported to produce severe cardiotoxic side effects, including coronary vasospasm, ventricular arrhythmias, and sudden cardiac death, and is not typically reported in individuals with pre-existing coronary vasospasm.

Author List

Tai S, Mohananey D, Griffiths C, Johnson B, Garg J, Ridolfi TJ, Lohr NL, Chakrabarti S, Brown SA

Authors

Divyanshu Mohananey MD Assistant Professor in the Medicine department at Medical College of Wisconsin
Timothy J. Ridolfi MD, MS, FACS Associate Professor in the Surgery department at Medical College of Wisconsin