Faculty Collaboration Database

Basic science of small cell lung cancer. Chest Surg Clin N Am 1997 Feb;7(1):1-19

Date

02/01/1997

Pubmed ID

9001753

DOI

10.1016/s1052-3359(25)00774-4

Scopus ID

2-s2.0-0031036319 (requires institutional sign-in at Scopus site)   26 Citations

Abstract

The unique phenotype expressed by small cell lung cancer (SCLC) cells is responsible for the distinct clinical behavior of SCLC. Basic research of SCLC is aimed at identifying and characterizing the unique attributes of SCLC cells that distinguish SCLC from other forms of lung cancer and contribute to the malignant behavior of SCLC. This article summarizes recent scientific advances in this area. Specific issues which are addressed include our current understanding of how SCLC arises, the origin and consequences of the neuroendocrine phenotype expressed by SCLC cells, and the role of SCLC adhesion molecules in SCLC metastasis.

Author List

Williams CL

Author

Carol L. Williams PhD Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Carcinoma, Small Cell
Cell Adhesion Molecules
Cocarcinogenesis
Genetic Predisposition to Disease
Humans
Karyotyping
Lung Neoplasms
Mutation
Neoplasm Metastasis
Phenotype
Prognosis
Smoking