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Platelet transfusion can be related to liver regeneration after living donor liver transplantation. World J Surg 2010 May;34(5):1052-8

Date

02/13/2010

Pubmed ID

20151125

DOI

10.1007/s00268-010-0464-x

Scopus ID

2-s2.0-77954694587 (requires institutional sign-in at Scopus site)   44 Citations

Abstract

BACKGROUND: Although liver regeneration is a fundamental aspect of living donor liver transplantation (LDLT), the factors that affect liver regeneration during the early post-transplantation period have not been thoroughly investigated. Recently it was suggested that platelets contribute to liver regeneration. The aim of the present study was to identify the major factors that affect liver graft regeneration during the early post-transplantation period.

MATERIALS AND METHODS: Eighty-seven right liver grafted, adult-to-adult LDLT patients were retrospectively analyzed. Liver regeneration was assessed by volumetry from computed tomographic (CT) scans obtained between the 9th and 11th postoperative days. The authors investigated relationships between clinical variables and liver graft regeneration rates, and they conducted multiple regression analysis on factors found to be significant by univariate analysis.

RESULTS: Mean graft weight at operation was 722.9 +/- 109.7 g, and mean graft volume assessed by follow-up CT was 1,042.2 +/- 155.6 ml, reflecting a mean liver graft regeneration of 45.9 +/- 22.3%. The graft regeneration was found to correlate inversely with graft-to-recipient weight ratio (GRWR, r = -0.406, p < 0.001) and directly with portal flow velocity (cm/s; r = 0.307; p = 0.004) and splenic index (cm(3); r = 0.282; p = 0.009). Moreover, the total amount (units) of platelets transfused was found to be significantly associated with graft regeneration (r = 0.293; p = -.006). Stepwise regression analysis showed that GRWR (beta = -33.124; p = 0.001), total amount of platelets transfused (beta = 0.771; p = 0.012), and splenic index (beta = -0.010; p = 0.049) were independently associated with graft regeneration.

CONCLUSIONS: The results of the present study suggest that platelets play a significant role in human liver regeneration after LDLT.

Author List

Kim J, Yi NJ, Shin WY, Kim T, Lee KU, Suh KS

Author

Joohyun Kim MD, PhD Associate Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Aged
Female
Humans
Liver Regeneration
Liver Transplantation
Living Donors
Male
Middle Aged
Platelet Transfusion
Retrospective Studies
Young Adult