Intergrader agreement of foveal cone topography measured using adaptive optics scanning light ophthalmoscopy. Biomed Opt Express 2022 Aug 01;13(8):4445-4454
Date
08/30/2022Pubmed ID
36032569Pubmed Central ID
PMC9408252DOI
10.1364/BOE.460821Scopus ID
2-s2.0-85135397395 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
The foveal cone mosaic can be directly visualized using adaptive optics scanning light ophthalmoscopy (AOSLO). Previous studies in individuals with normal vision report wide variability in the topography of the foveal cone mosaic, especially the value of peak cone density (PCD). While these studies often involve a human grader, there have been no studies examining intergrader reproducibility of foveal cone mosaic metrics. Here we re-analyzed published AOSLO foveal cone images from 44 individuals to assess the relationship between the cone density centroid (CDC) location and the location of PCD. Across 5 graders with variable experience, we found a measurement error of 11.7% in PCD estimates and higher intergrader reproducibility of CDC location compared to PCD location (p < 0.0001). These estimates of measurement error can be used in future studies of the foveal cone mosaic, and our results support use of the CDC location as a more reproducible anchor for cross-modality analyses.
Author List
Wynne N, Cava JA, Gaffney M, Heitkotter H, Scheidt A, Reiniger JL, Grieshop J, Yang K, Harmening WM, Cooper RF, Carroll JAuthors
Joseph J. Carroll PhD Director, Professor in the Ophthalmology and Visual Sciences department at Medical College of WisconsinRobert F. Cooper Ph.D Assistant Professor in the Biomedical Engineering department at Marquette University
Kai Yang PhD Assistant Professor in the Institute for Health and Equity department at Medical College of Wisconsin
