Oncocytic nodular hyperplasia of the thyroid. Ann Diagn Pathol 2022 Dec;61:152049
Date
09/27/2022Pubmed ID
36162158DOI
10.1016/j.anndiagpath.2022.152049Scopus ID
2-s2.0-85138430048 (requires institutional sign-in at Scopus site)Abstract
Nodular hyperplasia of the thyroid is a process whereby the gland experiences growth by nodular expansion of thyroid parenchyma. We have encountered 45 patients in whom the process was caused by the growth of well-defined and sharply circumscribed but unencapsulated nodules composed of oncocytic thyroid follicular cells. The lesions arose in 39 women and 6 men, aged 25-69 years (mean = 50.3 years). The surrounding thyroid parenchyma showed features of chronic lymphocytic thyroiditis. The nodules varied from microscopic to 5 cm and appeared to compress the surrounding thyroid parenchyma. Most of the lesions lacked a well-defined capsule. In 26 tumors, the nodules displayed a predominantly follicular pattern of growth; in 8 cases there were admixtures of follicular and trabecular patterns with focal solid areas devoid of follicles. Clinical follow-up in 39 patients ranging from 7 to 22 years (median = 16 years) showed no evidence of recurrence, metastasis, or malignant transformation. One patient died of unknown causes 15 years after the diagnosis, and another patient died 4 years after diagnosis from metastatic colonic adenocarcinoma. Oncocytic nodular hyperplasia is a benign process associated with chronic lymphocytic thyroiditis that should be distinguished from benign and malignant oncocytic (Hurthle cell) tumors of the thyroid.
Author List
Suster D, Ronen N, Giorgadze TAuthor
Tamara Giorgadze MD Professor in the Pathology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdenocarcinomaAdenoma, Oxyphilic
Female
Hashimoto Disease
Humans
Hyperplasia
Male
Oxyphil Cells
Thyroid Neoplasms
Thyroid Nodule
