Effect of Sickle Cell Anemia Therapies on the Natural History of Growth and Puberty Patterns. J Pediatr Hematol Oncol 2019 Nov;41(8):606-611
Date
04/06/2019Pubmed ID
30951025Pubmed Central ID
PMC6776732DOI
10.1097/MPH.0000000000001477Scopus ID
2-s2.0-85064228849 (requires institutional sign-in at Scopus site) 1 CitationAbstract
As pediatric patients with sickle cell anemia (SCA) have impaired growth and puberty patterns, we studied the effect of disease-modifying therapies on growth and puberty patterns for patients with SCA receiving hydroxyurea (HU), transfusions, or no therapy. We performed a retrospective study of children with SCA in whom anthropometric measurements and therapy type were recorded. Penalized smoothing splines were fitted to estimate growth curves and growth velocity, and linear mixed models were used to examine differences across treatment groups. Across group analyses were divided into early childhood (4.0 to 7.9 y) and peripubertal (8.0 to 12.0 y). We analyzed growth data on 157 SCA patients. From 8.0 to 12.0 years, girls on transfusion therapy were significantly taller than girls on HU (range, 5.7 to 7.2 cm; P-value range 0.002 to 0.01). From 10.0 to 12.0 years, boys on transfusion therapy were significantly taller than boys on HU (range, 4.1 to 9.4 cm; P-value range <0.0001 to 0.04). In addition, boys on transfusion therapy had an earlier peak height velocity as compared with boys on either HU or no therapy. In conclusion, children receiving transfusions tended to be taller than children on HU or no therapy. Children on HU did not demonstrate superior growth pattern when compared with children on no therapy in the peripubertal years.
Author List
Nagalapuram V, Kulkarni V, Leach J, Aban I, Sirigaddi K, Lebensburger JD, Iyer PAuthor
Pallavi Iyer MD Chief, Associate Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdolescent Development
Anemia, Sickle Cell
Blood Transfusion
Child
Child Development
Child, Preschool
Female
Humans
Infant
Infant, Newborn
Male
Puberty
Retrospective Studies
Sex Factors
